CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. Prednisone or Prednisolone, which are corticosteroids. Sometimes the chimeric anti-CD20 monoclonal antibody, rituximab, is added to this treatment regimen to form the R-CHOP chop suey. CHOP is generally used as first-line therapy.

Normal cells are more able than cancer cells to repair damage from chemotherapy drugs. The combination is generally well tolerated. Neutropenia generally develops in the second week. During this period, many clinicians recommend pegfilgrastim or prophylactic use of ciprofloxacin. Allopurinol is typically co-administered prophylactically to prevent hyperuricemia that results from tumor lysis syndrome, the result of rapid death of tumor cells.